Vaidyanathan S, Watt J W, Soni B M, Krishnan K R
Regional Spinal Injuries Centre, District General Hospital, Merseyside, UK.
Spinal Cord. 1996 Nov;34(11):691-5. doi: 10.1038/sc.1996.125.
Two patients with long-standing tetraplegia after spinal cord injury developed reflex penile erection in the operation theatre. One had not received any anaesthesia, and penile erection occurred after introduction of the cystoscope into the urethra, and also autonomic dysreflexia. Intravenous salbutamol, in a dose of 10 micrograms, produced immediate and persistent penile detumescence and salbutamol-induced fall in blood pressure was of therapeutic value. In the second patient, penile erection occurred during general anaesthesia prior to cystoscopy. Immediate and persistent penile detumescence was achieved with intravenous salbutamol 20 micrograms. There was transient fall of blood pressure which responded to intravenous infusion of 0.9% sodium chloride. Salbutamol-induced fall in blood pressure is of therapeutic value in those spinal cord injury patients who develop, in addition to penile erection, autonomic dysreflexia precipitated by urethral instrumentation, or bladder distension with the irrigating fluid. Intravenous salbutamol is preferable to intra-cavernosal phenylephrine, noradrenaline, metaraminol, and epinephrine, or intravenous ephedrine which are contraindicated in patients with hypertension.
两名脊髓损伤后长期四肢瘫痪的患者在手术室出现反射性阴茎勃起。其中一名患者未接受任何麻醉,在将膀胱镜插入尿道后出现阴茎勃起,同时伴有自主神经反射异常。静脉注射10微克沙丁胺醇后,阴茎立即持续消肿,且沙丁胺醇引起的血压下降具有治疗价值。在第二名患者中,阴茎勃起发生在膀胱镜检查前的全身麻醉期间。静脉注射20微克沙丁胺醇后阴茎立即持续消肿。血压出现短暂下降,静脉输注0.9%氯化钠后恢复。对于那些除阴茎勃起外,因尿道器械操作或膀胱被冲洗液扩张而引发自主神经反射异常的脊髓损伤患者,沙丁胺醇引起的血压下降具有治疗价值。静脉注射沙丁胺醇优于海绵体内注射去氧肾上腺素、去甲肾上腺素、间羟胺和肾上腺素,或静脉注射麻黄碱,因为高血压患者禁用这些药物。