McDonald M P, Crawley J N
Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA.
Behav Neurosci. 1996 Oct;110(5):1025-32. doi: 10.1037//0735-7044.110.5.1025.
Galanin is a 29-amino acid neuropeptide that coexists with acetylcholine in the medial septum/diagonal band in the rat and impairs choice accuracy on an operant delayed-nonmatching-to-position (DNMTP) working-memory task. M40, a peptidergic galanin antagonist, has previously been shown to block several physiological actions of galanin. The present experiments tested the ability of M40 to block the effects of galanin on DNMTP performance. M40 completely blocked choice-accuracy deficits induced by galanin administration in both the lateral ventricle and ventral hippocampus, at doses of M40 approximately 5-fold the molar dose of galanin. M40 appears to be an effective galanin antagonist in a rodent memory paradigm, indicating that this compound may prove useful in investigating the role of endogenous galanin in learning and memory.
甘丙肽是一种由29个氨基酸组成的神经肽，在大鼠的内侧隔区/斜角带中与乙酰胆碱共存，并损害操作性延迟位置不匹配（DNMTP）工作记忆任务中的选择准确性。M40是一种肽能甘丙肽拮抗剂，此前已被证明可阻断甘丙肽的多种生理作用。本实验测试了M40阻断甘丙肽对DNMTP表现影响的能力。M40在侧脑室和腹侧海马中均能完全阻断甘丙肽给药引起的选择准确性缺陷，其剂量约为甘丙肽摩尔剂量的5倍。在啮齿动物记忆范式中，M40似乎是一种有效的甘丙肽拮抗剂，这表明该化合物可能在研究内源性甘丙肽在学习和记忆中的作用方面具有一定价值。
