Robinson J K, Crawley J N
Unit on Behavioral Neuropharmacology, National Institute of Mental Health, Bethesda, Maryland 20892.
Behav Neurosci. 1993 Jun;107(3):458-67. doi: 10.1037//0735-7044.107.3.458.
Galanin is a neuroactive peptide that coexists with acetylcholine in the basal forebrain region. Galanin inhibits cholinergic functions in vitro and in vivo and has been shown to impair performance in some memory tasks. The present study compared the effects of galanin with the effects of scopolamine (a muscarinic antagonist) and ketamine and MK-801 (both NMDA receptor antagonists) on performance of an operant, spatial, delayed nonmatching-to-sample task in rats. Choice accuracy was impaired in a dose-dependent but delay-independent manner by galanin, scopolamine, and MK-801 but was not systematically influenced by ketamine. Measures of session duration, trials completed, discrimination accuracy, preservation, within-trial error distribution, and operant lever pressing were also analyzed. These results support observations that galanin disrupts performance in memory tasks requiring delayed responding but that the disruption is not specific to mnemonic capabilities.
甘丙肽是一种神经活性肽，与乙酰胆碱共存于基底前脑区域。甘丙肽在体外和体内均抑制胆碱能功能，并且已被证明会损害某些记忆任务的表现。本研究比较了甘丙肽与东莨菪碱（一种毒蕈碱拮抗剂）以及氯胺酮和MK - 801（均为NMDA受体拮抗剂）对大鼠操作性、空间性、延迟非匹配样本任务表现的影响。甘丙肽、东莨菪碱和MK - 801以剂量依赖性但与延迟无关的方式损害选择准确性，但氯胺酮未对其产生系统性影响。还分析了实验时长、完成的试验次数、辨别准确性、保存情况、试验内误差分布以及操作性杠杆按压等指标。这些结果支持以下观察结果：甘丙肽会干扰需要延迟反应的记忆任务的表现，但这种干扰并非特定于记忆能力。
