Janowski R, Coffinet L, Audouy H, Foliguet B
ENT Department, Central Hospital, Henri Poincare University, Nancy, France.
Rhinology. 1995 Dec;33(4):203-7.
Nasal secretions are known to play a role in respiratory tract and host defense. Besides the mucociliary transport and biochemical properties of the mucus, we hypothesize the role of a secretory leukocyte compartment. We designed a time-series study to count leukocytes in baseline, physically- and pharmacologically-induced secretions. Twenty-three healthy volunteers and 29 patients participated in the study. In healthy subjects, secretion weights significantly increased from 24 +/- 5 mg (mean +/- SEM) at baseline to 35 +/- 6 mg and 115 +/- 12 mg, respectively, in physically and methacholine-induced secretions (p < 0.05). The leukocyte count did not change between baseline (14,445 +/- 5,010) and physically induced secretions (13,396 +/- 6,8401), but significantly increased after methacholine (28,140 +/- 11,411; p = 0.02). Leukocyte differential counts showed, moreover, an increase of lymphocytes in the methacholine-induced compartment. In patients, secretion weights significantly increased from 70 +/- 12 mg at baseline to 117 +/- 22 mg and 223 +/- 28 mg, respectively. The leukocyte count significantly increased between baseline (172,109 +/- 95,890) and physically induced secretions (410,503 +/- 318,224; p = 0.02), but decreased after methacholine (112,774 +/- 54,860). These data argue for the existence of a secretory leukocyte compartment, with a subcompartment of surface and an intraglandular subcompartment of reserve, the kinetics of which are different in patients and control subjects.
众所周知，鼻腔分泌物在呼吸道和宿主防御中发挥作用。除了黏液纤毛运输和黏液的生化特性外，我们推测存在一个分泌性白细胞区室。我们设计了一项时间序列研究，以对基线、物理诱导和药物诱导分泌物中的白细胞进行计数。23名健康志愿者和29名患者参与了该研究。在健康受试者中，分泌物重量从基线时的24±5毫克（均值±标准误）分别显著增加至物理诱导分泌物时的35±6毫克和乙酰甲胆碱诱导分泌物时的115±12毫克（p<0.05）。白细胞计数在基线时（14,445±5,010）和物理诱导分泌物时（13,396±6,840）之间没有变化，但在乙酰甲胆碱刺激后显著增加（28,140±11,411；p=0.02）。此外，白细胞分类计数显示，乙酰甲胆碱诱导的区室中淋巴细胞增加。在患者中，分泌物重量从基线时的70±12毫克分别显著增加至117±22毫克和223±28毫克。白细胞计数在基线时（172,109±95,890）和物理诱导分泌物时（410,503±318,224；p=0.02）之间显著增加，但在乙酰甲胆碱刺激后下降（112,774±54,860）。这些数据支持存在一个分泌性白细胞区室，其包括一个表面亚区室和一个储备腺内亚区室，其动力学在患者和对照受试者中有所不同。
