Laine V J, Huupponen R, Kaila T, Gronroos J, Nevalainen T J
Department of Pathology, University of Turku, Finland.
Exp Toxicol Pathol. 1996 Jan;48(1):77-9. doi: 10.1016/S0940-2993(96)80096-0.
The effects of chronic alcohol intake and carbachol stimulation on pancreatic muscarinic receptor binding and insulin concentrations were studied in the rat pancreas. There was a strong correlation between the number of muscarinic receptors and the concentration of insulin in the pancreas. The concentration of insulin decreased in the pancreas after long-term ethanol exposure and increased after carbachol stimulation. These results indicate that the secretion of insulin is mediated via the muscarinic receptor pathway, and that the changes in the number of muscarinic receptors may have a role in insulin deficiency after long-term alcohol consumption.
在大鼠胰腺中研究了长期摄入酒精和卡巴胆碱刺激对胰腺毒蕈碱受体结合及胰岛素浓度的影响。胰腺中毒蕈碱受体数量与胰岛素浓度之间存在强相关性。长期乙醇暴露后胰腺中胰岛素浓度降低，卡巴胆碱刺激后胰岛素浓度升高。这些结果表明，胰岛素的分泌是通过毒蕈碱受体途径介导的，并且长期饮酒后毒蕈碱受体数量的变化可能在胰岛素缺乏中起作用。
