Susa I, Martiel J L
Techniques de l'Imagerie de la Modelisation et de la Cognition, Faculte de Medecine, La Tronche, France.
Acta Biotheor. 1995 Dec;43(4):335-49. doi: 10.1007/BF00713557.
Neurones with active conductance on dendrites integrate synaptic signals and modulate generation of axon spikes in a nonlinear way. Owing to experimental difficulties, modelling provides invaluable insight for the comprehension of neurone behaviour particularly when dendrites are excitable. We used experimental data obtained for the Anterior Gastric Receptor neurone (AGR neurone), which controls the lobster gastric mill activity, to derive a set of partial differential equations for the membrane voltage. Simulation showed that upon varying the intensity of stimulation on the dendrite, the response pattern between dendrites and axon activity continuously changes. In addition, when only half of the dendritic tree is active, axon firing exhibits regular oscillations and bursting activity. We discuss these results in relation with the experimental work done on the AGR neurone.
树突上具有主动电导的神经元以非线性方式整合突触信号并调节轴突峰电位的产生。由于实验困难，建模为理解神经元行为提供了宝贵的见解，特别是当树突具有兴奋性时。我们使用了从控制龙虾胃磨活动的前胃受体神经元（AGR神经元）获得的实验数据，来推导一组关于膜电压的偏微分方程。模拟表明，改变对树突的刺激强度时，树突和轴突活动之间的响应模式会持续变化。此外，当只有一半的树突树活跃时，轴突放电呈现规则振荡和爆发活动。我们结合对AGR神经元所做的实验工作来讨论这些结果。
