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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Chen C K, Pace-Asciak C R

Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.

Gen Pharmacol. 1996 Mar;27(2):363-6. doi: 10.1016/0306-3623(95)02001-2.

Both resveratrol and quercetin dose-dependently inhibited the contractile response to noradrenaline (NA) in isolated endothelium-intact rat aorta. This inhibitory effect on vascular contraction was blocked by pretreatment of the blood vessel with the nitric oxide (NO) synthase inhibitor, L-NNA (1 microM). 2. Quercetin at a concentration > 1 x 10(-5) M, and resveratrol at > 3 x 10(-5) M, caused relaxation of the phenylephrine (PE) precontracted endothelium-intact aorta, and L-NNA, at 1 x 10(-6) M, reversed the relaxation. 3. At higher concentrations, > 6 x 10(-5) M, resveratrol and quercetin also relaxed the endothelium-denuded aortic rings. However, this effect could not be reversed by the NO inhibitor. 4. It is concluded that resveratrol and quercetin exert both indirect and direct vasodilator effects on the blood vessel by nitric oxide-mediated and non-NO-mediated mechanisms, respectively.

白藜芦醇和槲皮素均剂量依赖性地抑制离体的、内皮完整的大鼠主动脉对去甲肾上腺素（NA）的收缩反应。用一氧化氮（NO）合酶抑制剂L-NNA（1微摩尔）预处理血管可阻断这种对血管收缩的抑制作用。2. 浓度大于1×10⁻⁵ M的槲皮素和大于3×10⁻⁵ M的白藜芦醇可使苯肾上腺素（PE）预收缩的、内皮完整的主动脉舒张，而1×10⁻⁶ M的L-NNA可逆转这种舒张。3. 在更高浓度（大于6×10⁻⁵ M）时，白藜芦醇和槲皮素也可使去内皮的主动脉环舒张。然而，这种作用不能被NO抑制剂逆转。4. 结论是，白藜芦醇和槲皮素分别通过NO介导和非NO介导的机制对血管发挥间接和直接的血管舒张作用。

Chen C K, Pace-Asciak C R

Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.

Gen Pharmacol. 1996 Mar;27(2):363-6. doi: 10.1016/0306-3623(95)02001-2.

Both resveratrol and quercetin dose-dependently inhibited the contractile response to noradrenaline (NA) in isolated endothelium-intact rat aorta. This inhibitory effect on vascular contraction was blocked by pretreatment of the blood vessel with the nitric oxide (NO) synthase inhibitor, L-NNA (1 microM). 2. Quercetin at a concentration > 1 x 10(-5) M, and resveratrol at > 3 x 10(-5) M, caused relaxation of the phenylephrine (PE) precontracted endothelium-intact aorta, and L-NNA, at 1 x 10(-6) M, reversed the relaxation. 3. At higher concentrations, > 6 x 10(-5) M, resveratrol and quercetin also relaxed the endothelium-denuded aortic rings. However, this effect could not be reversed by the NO inhibitor. 4. It is concluded that resveratrol and quercetin exert both indirect and direct vasodilator effects on the blood vessel by nitric oxide-mediated and non-NO-mediated mechanisms, respectively.

白藜芦醇和槲皮素均剂量依赖性地抑制离体的、内皮完整的大鼠主动脉对去甲肾上腺素（NA）的收缩反应。用一氧化氮（NO）合酶抑制剂L-NNA（1微摩尔）预处理血管可阻断这种对血管收缩的抑制作用。2. 浓度大于1×10⁻⁵ M的槲皮素和大于3×10⁻⁵ M的白藜芦醇可使苯肾上腺素（PE）预收缩的、内皮完整的主动脉舒张，而1×10⁻⁶ M的L-NNA可逆转这种舒张。3. 在更高浓度（大于6×10⁻⁵ M）时，白藜芦醇和槲皮素也可使去内皮的主动脉环舒张。然而，这种作用不能被NO抑制剂逆转。4. 结论是，白藜芦醇和槲皮素分别通过NO介导和非NO介导的机制对血管发挥间接和直接的血管舒张作用。