Dolezalová V, Simícková M, Stratil P
J Toxicol Environ Health. 1979 Mar-May;5(2-3):357-70. doi: 10.1080/15287397909529753.
Recent findings concerning the significance of alpha 1-fetoprotein (AFP) as a tool for clinical diagnosis and monitoring of tumor diseases are reviewed briefly. The applicability of this protein marker to the early diagnosis of patients at carcinogenic risk is discussed. In addition, experimental data obtained with a model of chemical hepatocarcinogenesis are reported. The increase of proliferative activity in precancerous liver tissue preceded AFP production under experimental conditions with azodyes and aflatoxin B1 as carcinogens. Immunohistochemical analysis of the relation of AFP to changes of cell populations and to liver tissue rearrangement led to the conclusion that AFP-producing cells cannot be precursors of malignant hepatocytes; however, AFP appeared to be linked to dividing hepatocytes at a certain step of cell differentiation regardless of the stages of precancerous development. A decrease in the rate of nuclear RNA synthesis was observed in both precancerous and tumor tissues. A possible analogy between the early phase of AFP production in animal carcinogenesis and that in human carcinogenesis is considered.
本文简要回顾了近期关于甲胎蛋白（AFP）作为肿瘤疾病临床诊断和监测工具的重要性的研究发现。讨论了这种蛋白质标志物在致癌风险患者早期诊断中的适用性。此外，还报告了用化学性肝癌发生模型获得的实验数据。在以偶氮染料和黄曲霉毒素B1作为致癌物的实验条件下，癌前肝组织中增殖活性的增加先于AFP的产生。对AFP与细胞群体变化及肝组织重排关系的免疫组织化学分析得出结论：产生AFP的细胞不可能是恶性肝细胞的前体；然而，无论癌前发展阶段如何，AFP似乎在细胞分化的某一阶段与正在分裂的肝细胞有关。在癌前组织和肿瘤组织中均观察到核RNA合成速率的降低。考虑了动物致癌过程中AFP产生早期阶段与人类致癌过程中AFP产生早期阶段可能存在的相似性。
