Schnieder T, Kordes S, Epe C, Kuschfeldt S, Stoye M
Institute of Parasitology, School of Veterinary Medicine, Hannover, Germany.
Zentralbl Veterinarmed B. 1996 Mar;43(1):35-43. doi: 10.1111/j.1439-0450.1996.tb00285.x.
The aim of this investigation was to examine whether the treatment of bitches with doramectin is able to prevent pre-natal and galactogenic infections with Toxocara canis in their pups. Five experimentally infected beagle bitches were treated subcutaneously with 1 mg doramectin per kg body weight on each of days 40 and 55 of their pregnancy. Another infected bitch served as an untreated control. The efficacy of the medication was examined by counting the intestinal stages and somatic larvae in bitches and pups. The treatment did not completely prevent perinatal infections with T. canis. Intestinal stages and/or somatic larvae occurred in 16 of 20 pups. Seven pups developed patent infections. Compared to the control pups, the average worm burden (intestinal stages) of pups from treated bitches was less than 1%. No impairment of condition or physical development was noticed in the pups during the investigations. From the second week of life, the pups of the non-medicated bitch showed signs of a severe toxocarosis. No side effects were seen in the bitches after treatment with doramectin.
本研究的目的是检验用多拉菌素治疗母犬是否能够预防其幼犬的产前和产乳期犬弓首蛔虫感染。五只经实验感染的比格母犬在其妊娠的第40天和第55天，每只皮下注射1毫克/千克体重的多拉菌素。另一只感染母犬作为未治疗的对照。通过计数母犬和幼犬体内的肠道期幼虫和体壁幼虫来检验药物的疗效。该治疗未能完全预防犬弓首蛔虫的围产期感染。20只幼犬中有16只出现肠道期幼虫和/或体壁幼虫。7只幼犬发生显性感染。与对照幼犬相比，经治疗母犬所生幼犬的平均虫负荷（肠道期幼虫）不到1%。在研究期间，未注意到幼犬的健康状况或身体发育受到损害。从出生后第二周起，未用药母犬所生幼犬出现严重弓首蛔虫病的症状。用多拉菌素治疗后，母犬未出现副作用。
