• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Mapping variation in chromosome homologues of different Giardia strains.

作者信息

Upcroft J A, Chen N, Upcroft P

机构信息

Bancroft Centre, Queensland Institute of Medical Research, Australia.

出版信息

Mol Biochem Parasitol. 1996 Feb-Mar;76(1-2):135-43. doi: 10.1016/0166-6851(95)02554-5.

DOI:10.1016/0166-6851(95)02554-5
PMID:8920002
Abstract

A landmark physical map of the 2-Mb chromosome of the Giardia duodenalis cloned line WB-1B, constructed using randomly cloned, chromosome specific markers, was used to compare the organisation and map order of the equivalent chromosome in other strains. A representative marker from each of the 13 NotI segments of the 2-Mb chromosome was hybridized to NotI cleavages of whole chromosomes of the other strains. Two strains, one isolated from a human, and one from a cat, had the same chromosome hybridization patterns as WB-1B. A strain isolated from a sheep, had one NotI chromosome 5 segment larger than WB-1B. Two additional strains isolated from a calf and a human had significantly different NotI cleavage patterns from the previous strains and shared no similar-sized chromosome NotI segment from their 2Mb chromosome homologues and only one in common with WB-1B. In one strain, two markers from the same WB-1B NotI segment did not hybridize suggesting deletion events have occurred. The order of some NotI segments within the 2Mb chromosome homologue was maintained, as determined from partial NotI chromosome cleavages, while in the most divergent of strains internal chromosome rearrangements and deletions were evident. All but one of the 2Mb WB-1B chromosome markers examined hybridized to a single chromosome band in all strains. Thus, while Giardia chromosomes vary in size, copy number and organisation, some linkage of markers is apparently maintained in isolates from disparate hosts and localities. We have therefore generated a genetic analysis system for Giardia with landmark maps using representative markers to replace the paucity of classical genetic markers and mutants. This approach is being extended to the complete genome.

摘要

相似文献

1
Mapping variation in chromosome homologues of different Giardia strains.
Mol Biochem Parasitol. 1996 Feb-Mar;76(1-2):135-43. doi: 10.1016/0166-6851(95)02554-5.
2
Physical map of a 2 Mb chromosome of the intestinal protozoan parasite Giardia duodenalis.肠道原生动物寄生虫十二指肠贾第虫2兆碱基染色体的物理图谱。
Chromosome Res. 1994 Jul;2(4):307-13. doi: 10.1007/BF01552724.
3
Chromosomal duplication in Giardia duodenalis.十二指肠贾第虫的染色体复制
Int J Parasitol. 1993 Aug;23(5):609-16. doi: 10.1016/0020-7519(93)90167-w.
4
Sequence map of the 3-Mb Giardia duodenalis assemblage A chromosome.十二指肠贾第虫 A 组合 3-Mb 序列图谱。
Chromosome Res. 2009;17(8):1001-14. doi: 10.1007/s10577-009-9084-4. Epub 2009 Oct 16.
5
[NotI-STS markers for human chromosome 3 are gene markers].
Mol Biol (Mosk). 2005 Jul-Aug;39(4):687-701.
6
Molecular analysis of human chromosome 16 cosmid clones containing NotI sites.对含NotI位点的人类16号染色体黏粒克隆进行分子分析。
Mamm Genome. 1992;3(2):92-100. doi: 10.1007/BF00431252.
7
Development and utilization of a somatic cell hybrid mapping panel to assign NotI linking probes to the long arm of human chromosome 6.用于将NotI连接探针定位到人类6号染色体长臂的体细胞杂交定位板的开发与应用
Genomics. 1992 Mar;12(3):542-8. doi: 10.1016/0888-7543(92)90446-y.
8
A NotI restriction map of the entire long arm of human chromosome 21.人类21号染色体整个长臂的NotI限制酶切图谱。
Nat Genet. 1993 Aug;4(4):361-6. doi: 10.1038/ng0893-361.
9
An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3 (AP20) region implicated in major human epithelial malignancies.与主要人类上皮恶性肿瘤相关的3.5兆碱基3号染色体3p21.3(AP20)区域的综合物理图谱和基因图谱。
Cancer Res. 2003 Jan 15;63(2):404-12.
10
Giardia sp.: comparison of electrophoretic karyotypes.贾第虫属:电泳核型比较
Exp Parasitol. 1990 Nov;71(4):470-82. doi: 10.1016/0014-4894(90)90073-l.

引用本文的文献

1
Genomic survey maps differences in the molecular complement of vesicle formation machinery between Giardia intestinalis assemblages.基因组调查绘制了肠道贾第鞭毛虫不同组合之间囊泡形成机制分子组成的差异图谱。
PLoS Negl Trop Dis. 2023 Dec 18;17(12):e0011837. doi: 10.1371/journal.pntd.0011837. eCollection 2023 Dec.
2
Data from a proteomic baseline study of Assemblage A in Giardia duodenalis.来自十二指肠贾第鞭毛虫组合A蛋白质组基线研究的数据。
Data Brief. 2015 Aug 19;5:23-7. doi: 10.1016/j.dib.2015.08.003. eCollection 2015 Dec.
3
Albendazole and its derivative JVG9 induce encystation on Giardia intestinalis trophozoites.
阿苯达唑及其衍生物 JVG9 诱导贾第虫肠滋养体形成囊前期。
Parasitol Res. 2013 Sep;112(9):3251-7. doi: 10.1007/s00436-013-3521-1. Epub 2013 Jul 16.
4
Transition of a microRNA from repressing to activating translation depending on the extent of base pairing with the target.根据 miRNA 与靶标配对程度的不同,miRNA 可从抑制翻译转变为激活翻译。
PLoS One. 2013;8(2):e55672. doi: 10.1371/journal.pone.0055672. Epub 2013 Feb 6.
5
Chromosome sequence maps of the Giardia lamblia assemblage A isolate WB.贾第虫 A 组 WB 分离株的染色体序列图谱。
Trends Parasitol. 2010 Oct;26(10):484-91. doi: 10.1016/j.pt.2010.07.002. Epub 2010 Aug 24.
6
Sequence map of the 3-Mb Giardia duodenalis assemblage A chromosome.十二指肠贾第虫 A 组合 3-Mb 序列图谱。
Chromosome Res. 2009;17(8):1001-14. doi: 10.1007/s10577-009-9084-4. Epub 2009 Oct 16.
7
Cytogenetic evidence for diversity of two nuclei within a single diplomonad cell of Giardia.贾第虫单个双滴虫细胞内两个细胞核存在差异的细胞遗传学证据。
Chromosoma. 2007 Feb;116(1):65-78. doi: 10.1007/s00412-006-0082-4. Epub 2006 Nov 4.
8
Rearranged subtelomeric rRNA genes in Giardia duodenalis.十二指肠贾第虫中重排的亚端粒rRNA基因。
Eukaryot Cell. 2005 Feb;4(2):484-6. doi: 10.1128/EC.4.2.484-486.2005.