鞘内注射μ、δ和κ阿片受体激动剂对兔心血管系统的影响。

Cardiovascular effects of intrathecally injected mu, delta and kappa opioid receptor agonists in rabbits.

Oğütman C, Kaputlu I, Sadan G

Department of Pharmacology, School of Medicine, Akdeniz University, Antalya, Turkey.

J Auton Pharmacol. 1995 Dec;15(6):443-50. doi: 10.1111/j.1474-8673.1995.tb00409.x.

Abstract

Intrathecal saline, the mu opioid agonist [D-Ala2, MePhe4, Gly5-ol] enkephalin (DAGO) and delta opioid agonist [D-Pen2, D-Pen5] enkephalin (DPDPE) had no significant effects on systemic blood pressure and heart rate values. 2. The kappa opioid agonist bremazocine however, caused falls in blood pressure and reduction in heart rate. 3. Intrathecal administration of saline, DPDPE and bremazocine had no effect on baroreflex sensitivity. 4. Intrathecal administration of DAGO caused a reduction in baroreflex sensitivity; this effect was inhibited by naloxone and abolished after atenolol. 5. The role of spinal opioid systems as a possible site of action is discussed.

摘要

鞘内注射生理盐水、μ阿片受体激动剂[D - Ala2，MePhe4，Gly5 - ol]脑啡肽（DAGO）和δ阿片受体激动剂[D - Pen2，D - Pen5]脑啡肽（DPDPE）对全身血压和心率值无显著影响。2. 然而，κ阿片受体激动剂布马佐辛可导致血压下降和心率降低。3. 鞘内注射生理盐水、DPDPE和布马佐辛对压力反射敏感性无影响。4. 鞘内注射DAGO可导致压力反射敏感性降低；这种作用被纳洛酮抑制，且在阿替洛尔作用后消失。5. 讨论了脊髓阿片系统作为可能作用部位的作用。