[APC基因]
[The APC gene].
作者信息
Akiyama T
机构信息
Department of Oncogene Research, Osaka University.
出版信息
Nihon Rinsho. 1996 Apr;54(4):955-9.
PMID:8920656
Abstract
The tumor suppressor gene APC is mutated in most cases of familial adenomatous polyposis (FAP) and sporadic colorectal tumors. The product of the APC gene is a 300 kDa protein present in the cytoplasm as a homodimer. Interestingly, the APC protein is known to interact with the adherence junction protein catenin, suggesting that APC may be involved in cell adhesion. More recently we have demonstrated that overexpression of APC blocks cell cycle progression from the G0/G1 to the S phase.
摘要
肿瘤抑制基因APC在大多数家族性腺瘤性息肉病（FAP）和散发性结直肠癌病例中发生突变。APC基因的产物是一种300 kDa的蛋白质，以同二聚体形式存在于细胞质中。有趣的是，已知APC蛋白与黏附连接蛋白连环蛋白相互作用，这表明APC可能参与细胞黏附。最近我们证明，APC的过表达会阻断细胞周期从G0/G1期向S期的进展。
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