Shiotani A
Second Department of Internal Medicine, Wakayama Medical College.
Nihon Rinsho. 1996 Apr;54(4):1087-91.
Epidermal growth factor (EGF) and phorbol esters stimulate the human gastrin promoter through a novel GC-rich DNA element 5'-68GGGGCGGGGTGGGGGG-53 called gERE (gastrin EGF response element). The transcription factor Sp1 and two fast migrating complexes designated gastrin EGF response proteins (gERP1 and gERP2) bind to gERE. Sp1 binds to the 5' half site and gERP bind to the 3' half site. Both the 5' and 3' domains and some overlap between the two domains are required to confer EGF induction. Complex interactions between Sp1 and other factors binding to overlapping gERE half-sites confer EGF responsiveness to the gastrin promoter.
表皮生长因子（EGF）和佛波酯通过一个名为gERE（胃泌素EGF反应元件）的富含GC的新型DNA元件5'-68GGGGCGGGGTGGGGGG-53刺激人胃泌素启动子。转录因子Sp1和两种快速迁移的复合物，即胃泌素EGF反应蛋白（gERP1和gERP2）与gERE结合。Sp1结合5'半位点，gERP结合3'半位点。5'和3'结构域以及两个结构域之间的一些重叠对于赋予EGF诱导作用是必需的。Sp1与结合重叠gERE半位点的其他因子之间的复杂相互作用赋予胃泌素启动子EGF反应性。
