Funakoshi A
Department of Gastroenterology, National Kyushu Cancer Center.
Nihon Rinsho. 1996 Apr;54(4):1097-1103.
Cholecystokinin (CCK) act as hormones and neuropeptides on central and peripheral CCK receptors. The application of modern molecular biological techniques has identified two CCK receptors, CCK-A receptor (CCKAR) and CCK-B/gastrin receptor (CCKBR). The genes of CCKAR and CCKBR consist of five exons interrupted by four introns. We have reported that OLETF rats, which have been established as an animal model of NIDDM, revealed no expression of CCKAR gene (a naturally occurring CCKAR gene knockout rat). Pancreatic exocrine functions in OLETF rats are regulated by all neural and peptidergic agents except CCK. Therefore, we have proposed that OLETF rats may be a useful experimental model for examining the biological functions of the CCKAR.
胆囊收缩素（CCK）作为激素和神经肽作用于中枢和外周的CCK受体。现代分子生物学技术的应用已鉴定出两种CCK受体，即CCK-A受体（CCKAR）和CCK-B/胃泌素受体（CCKBR）。CCKAR和CCKBR的基因由五个外显子组成，中间被四个内含子隔开。我们曾报道，已被确立为非胰岛素依赖型糖尿病（NIDDM）动物模型的OLETF大鼠未显示CCKAR基因的表达（一种自然发生的CCKAR基因敲除大鼠）。除CCK外，所有神经和肽能介质均可调节OLETF大鼠的胰腺外分泌功能。因此，我们提出OLETF大鼠可能是用于研究CCKAR生物学功能的有用实验模型。
