Hurych J, Mirejovska E, Holusa R, Bubenikova D
National Institute of Public Health, Centre of Industrial Hygiene and Occupational Diseases, Prague, Czech Republic.
Toxicol Lett. 1996 Nov;88(1-3):305-11. doi: 10.1016/0378-4274(96)03754-x.
Lung injury elicited by a single intratracheal instillation of fibrogenic (quartz) and nuisance (anatase) dusts and/or weekly repeated instillation of CdCl2 solution combined with sinusoidal (50 Hz, 10 mT) magnetic field (MF) exposure was studied in male rats. Combined effects in bronchoalveolar lavage (BAL), rat lungs and regional lymph nodes after 4 months of MF exposure (1 h/5 days per week) were evaluated biochemically and by cytological and histopathological examination. Damage of cell membranes in the cell part of BAL due to MF exposure was not observed in the examined animal groups. Following MF exposure, decreased synthesis of collagen proteins (incorporation of [14C]proline) was demonstrated in lungs with quartz dust burden. Histological examination revealed differences in the lung tissue reaction suggesting the modification of the repair process due to MF exposure following experimental injury in both quartz and cadmium groups.
在雄性大鼠中研究了通过气管内单次注入致纤维化（石英）和无害（锐钛矿）粉尘和/或每周重复注入CdCl2溶液并结合正弦（50Hz，10mT）磁场（MF）暴露所引发的肺损伤。在MF暴露4个月后（每周5天，每天1小时），通过生化、细胞学和组织病理学检查评估支气管肺泡灌洗（BAL）、大鼠肺和局部淋巴结中的联合效应。在所检查的动物组中未观察到由于MF暴露导致BAL细胞部分细胞膜的损伤。MF暴露后，在有石英粉尘负荷的肺中，胶原蛋白的合成（[14C]脯氨酸的掺入）减少。组织学检查显示肺组织反应存在差异，表明在石英和镉组中，实验性损伤后由于MF暴露而使修复过程发生了改变。
