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1
Circadian regulation of hydroxyindole-O-methyltransferase mRNA in the chicken pineal gland in vivo and in vitro.鸡松果体中羟吲哚-O-甲基转移酶mRNA在体内和体外的昼夜节律调节
Biochem J. 1996 Nov 1;319 ( Pt 3)(Pt 3):761-6. doi: 10.1042/bj3190761.
2
Transcriptional regulation of hydroxyindole O-methyltransferase in the chicken pineal gland: day/night changes and long-term effects of light and darkness.鸡松果体中羟吲哚O-甲基转移酶的转录调控：昼夜变化以及光照和黑暗的长期影响。
Biochem J. 1993 Mar 15;290 ( Pt 3)(Pt 3):661-4. doi: 10.1042/bj2900661.
3
Melatonin synthesis pathway: circadian regulation of the genes encoding the key enzymes in the chicken pineal gland and retina.褪黑素合成途径：鸡松果体和视网膜中编码关键酶的基因的昼夜节律调节。
Reprod Nutr Dev. 1999 May-Jun;39(3):325-34. doi: 10.1051/rnd:19990305.
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Cyclic AMP increases hydroxyindole-O-methyltransferase mRNA levels in the chicken pineal gland, but is not required for circadian rhythmicity of this transcript.环磷酸腺苷（cAMP）可提高鸡松果体中羟吲哚-O-甲基转移酶的mRNA水平，但该转录本的昼夜节律性并不需要cAMP。
Brain Res. 1999 Jul 24;835(2):97-103. doi: 10.1016/s0006-8993(99)01456-0.
5
[Transcriptional regulation of an enzyme involved in the synthesis of melatonin].[参与褪黑素合成的一种酶的转录调控]
C R Seances Soc Biol Fil. 1993;187(1):69-76.
6
Circadian regulation of hydroxyindole-O-methyltransferase mRNA levels in rat pineal and retina.大鼠松果体和视网膜中羟吲哚-O-甲基转移酶mRNA水平的昼夜节律调节。
Brain Res. 1996 Oct 21;737(1-2):99-109. doi: 10.1016/0006-8993(96)00632-4.
7
Regulation of hydroxyindole-O-methyltransferase gene expression in the pineal gland and retina.松果体和视网膜中羟吲哚-O-甲基转移酶基因表达的调控。
Acta Neurobiol Exp (Wars). 1994;54 Suppl:41-6.
8
Photoneural regulation of rat pineal hydroxyindole-O-methyltransferase (HIOMT) messenger ribonucleic acid expression: an analysis of its complex relationship with HIOMT activity.大鼠松果体羟吲哚-O-甲基转移酶（HIOMT）信使核糖核酸表达的光神经调节：对其与HIOMT活性复杂关系的分析
Endocrinology. 1999 Mar;140(3):1375-84. doi: 10.1210/endo.140.3.6552.
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Hydroxyindole-O-methyltransferase in the chicken retina: immunocytochemical localization and daily rhythm of mRNA.鸡视网膜中的羟基吲哚-O-甲基转移酶：免疫细胞化学定位及mRNA的日节律
Eur J Neurosci. 1996 Apr;8(4):710-5. doi: 10.1111/j.1460-9568.1996.tb01256.x.
10
Long-term effects of constant light or darkness on chicken pineal hydroxyindole-O-methyltransferase expression: biochemical and cellular aspects.持续光照或黑暗对鸡松果体羟吲哚 - O - 甲基转移酶表达的长期影响：生化与细胞层面
Cell Mol Neurobiol. 1992 Apr;12(2):177-84. doi: 10.1007/BF00713371.

本文引用的文献

1
CONTROL OF HYDROXYINDOLE O-METHYLTRANSFERASE ACTIVITY IN THE RAT PINEAL GLAND BY ENVIRONMENTAL LIGHTING.环境光照对大鼠松果体中羟基吲哚-O-甲基转移酶活性的调控
J Biol Chem. 1965 Feb;240:949-54.
2
CIRCADIAN AND ESTROUS RHYTHMS IN PINEAL MELATONIN AND 5-HYDROXY INDOLE-3-ACETIC ACID.松果体褪黑素与5-羟吲哚-3-乙酸的昼夜节律和发情周期节律
Proc Soc Exp Biol Med. 1964 Mar;115:710-3. doi: 10.3181/00379727-115-29014.
3
Circadian regulation of iodopsin gene expression in embryonic photoreceptors in retinal cell culture.视网膜细胞培养中胚胎光感受器视锥视蛋白基因表达的昼夜节律调节。
Neuron. 1993 Apr;10(4):579-84. doi: 10.1016/0896-6273(93)90161-j.
4
Transcriptional regulation of hydroxyindole O-methyltransferase in the chicken pineal gland: day/night changes and long-term effects of light and darkness.鸡松果体中羟吲哚O-甲基转移酶的转录调控：昼夜变化以及光照和黑暗的长期影响。
Biochem J. 1993 Mar 15;290 ( Pt 3)(Pt 3):661-4. doi: 10.1042/bj2900661.
5
Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, an early response repressor.CREM的诱导性和负向自动调节：一个替代启动子指导早期反应抑制因子ICER的表达。
Cell. 1993 Dec 3;75(5):875-86. doi: 10.1016/0092-8674(93)90532-u.
6
Tryptophan hydroxylase expression is regulated by a circadian clock in Xenopus laevis retina.非洲爪蟾视网膜中的生物钟可调节色氨酸羟化酶的表达。
J Neurochem. 1994 Jun;62(6):2420-8. doi: 10.1046/j.1471-4159.1994.62062420.x.
7
Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless.果蝇突变体无时间蛋白中昼夜节律行为节律和周期RNA振荡的丧失。
Science. 1994 Mar 18;263(5153):1603-6. doi: 10.1126/science.8128246.
8
c-fos mRNA in the suprachiasmatic nuclei in vitro shows a circadian rhythm and responds to a serotonergic agonist.体外视交叉上核中的c-fos信使核糖核酸呈现昼夜节律，并对血清素能激动剂产生反应。
Brain Res Mol Brain Res. 1994 Aug;25(1-2):151-6. doi: 10.1016/0169-328x(94)90292-5.
9
Pinopsin is a chicken pineal photoreceptive molecule.视蛋白是一种鸡松果体感光分子。
Nature. 1994 Nov 3;372(6501):94-7. doi: 10.1038/372094a0.
10
Pineal opsin: a nonvisual opsin expressed in chick pineal.松果体视蛋白：一种在鸡松果体中表达的非视觉视蛋白。
Science. 1995 Mar 10;267(5203):1502-6. doi: 10.1126/science.7878470.

鸡松果体中羟吲哚-O-甲基转移酶mRNA在体内和体外的昼夜节律调节

Circadian regulation of hydroxyindole-O-methyltransferase mRNA in the chicken pineal gland in vivo and in vitro.

作者信息

Grève P, Voisin P, Grechez-Cassiau A, Bernard M, Collin J P, Guerlotté J

机构信息

Laboratoire de Neurobiologie Cellulaire, URA CNRS 1869, Poitiers, France.

出版信息

Biochem J. 1996 Nov 1;319 ( Pt 3)(Pt 3):761-6. doi: 10.1042/bj3190761.

DOI:10.1042/bj3190761
PMID:8920978
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1217854/
Abstract

The production of the pineal hormone melatonin displays circadian variations with high levels at night. The last enzyme involved in melatonin biosynthesis is hydroxyindole-O-methyltransferase (HIOMT, EC 2.1.1.4). The expression of the mRNA encoding chicken HIOMT was investigated in vivo and in vitro throughout the light/dark cycle, in constant darkness and with light interruption of the dark phase. The stability of HIOMT mRNA was also examined. A day/night rhythm of HIOMT mRNA levels, with a peak at the midlight phase, was observed in vivo as well as in vitro. Constant darkness did not abolish this rhythm in vivo. One cycle of the HIOMT mRNA rhythm could be observed in constant darkness in vitro. In addition, a stimulatory effect of light on HIOMT mRNA levels during the dark phase could be observed in vivo as well as in vitro. HIOMT mRNA stability was not affected by light or dark conditions, as demonstrated by chase experiments with actinomycin D. The results indicate that the daily changes in HIOMT mRNA concentration reflect transcriptional regulation by circadian oscillators and photosensory mechanisms that are endogenous to the pineal gland.

摘要

松果体激素褪黑素的分泌呈现出昼夜变化，夜间水平较高。参与褪黑素生物合成的最后一种酶是羟吲哚 - O - 甲基转移酶（HIOMT，EC 2.1.1.4）。在整个光/暗周期、持续黑暗以及暗期有光照中断的情况下，对编码鸡HIOMT的mRNA表达进行了体内和体外研究。还检测了HIOMT mRNA的稳定性。在体内和体外均观察到HIOMT mRNA水平的昼夜节律，在光照中期达到峰值。持续黑暗并未消除体内的这种节律。在体外持续黑暗条件下可观察到HIOMT mRNA节律的一个周期。此外，在体内和体外均可观察到暗期光照对HIOMT mRNA水平有刺激作用。如用放线菌素D进行追踪实验所示，HIOMT mRNA稳定性不受光照或黑暗条件影响。结果表明，HIOMT mRNA浓度的每日变化反映了松果体内源性昼夜振荡器和光感机制的转录调控。