Kha H, Li Y S, Deuel T F
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Genomics. 1996 Oct 15;37(2):242-4. doi: 10.1006/geno.1996.0550.
The retinoid acid inducible midkine gene encodes a highly basic, heparin-binding protein that possesses potential functions of growth or differentiation during the early stages of mouse embryonic development. Midkine gene has been mapped to mouse Chromosome 2. Here we report that the midkine gene is located in close proximity to the m4 muscarinic acid receptor gene. M4 codes for a transmembrane G protein that functions to transduce the action of acetylcholine neural transmitters in the nervous system. The two genes have the directions of their transcriptions running toward one another, and the distance between their respective 3' ends is approximately 1.3 kb.
维甲酸诱导中期因子基因编码一种高度碱性的、肝素结合蛋白，该蛋白在小鼠胚胎发育早期具有生长或分化的潜在功能。中期因子基因已被定位到小鼠2号染色体上。在此我们报告，中期因子基因与M4毒蕈碱酸受体基因紧密相邻。M4编码一种跨膜G蛋白，其功能是在神经系统中传导乙酰胆碱神经递质的作用。这两个基因的转录方向彼此相对，它们各自3'端之间的距离约为1.3 kb。
