Penttinen J, Valonen P
Kuopio Regional Institute of Occupational Health, Finland.
Int J Epidemiol. 1996 Aug;25(4):760-2. doi: 10.1093/ije/25.4.760.
In 1992 Thorogood et al. reported an increased risk of myocardial infarction in women using psychotropic drugs. The aim of our study is to find out whether there is a link between the use of psychotropic drugs and subsequent myocardial infarction in males.
A cohort of 3172 male farmers was followed from 1 February 1980 to 31 December 1992. Those subjects who had myocardial infarction without any previous symptoms during the follow-up were considered as cases. For every case three matched controls were selected. The matched variables were age, smoking habits, social status and county. The final sample includes 83 cases and 249 controls.
Those who had used psychotropic drugs had increased risk for myocardial infarction, odds ratio (OR) = 2.5, 95% confidence interval (CI):1.2-5.2. Most pronounced risk for myocardial infarction was found among users of anti-depressants, OR = 5.4 (CI:1.8-16.1).
The use of psychotropic drugs, especially antidepressants, is associated with increased risk of myocardial infarction. Further attempts are needed to determine whether the relationship between use of psychotropic drugs and risk of myocardial infarction is causal or not.
1992年，索罗古德等人报告称，使用精神药物的女性患心肌梗死的风险增加。我们研究的目的是找出男性使用精神药物与随后发生心肌梗死之间是否存在联系。
对3172名男性农民组成的队列进行了从1980年2月1日至1992年12月31日的随访。那些在随访期间无任何先前症状而发生心肌梗死的受试者被视为病例。为每个病例选择三个匹配的对照。匹配变量为年龄、吸烟习惯、社会地位和所在县。最终样本包括83例病例和249名对照。
使用精神药物的人患心肌梗死的风险增加，比值比（OR）=2.5，95%置信区间（CI）：1.2 - 5.2。在抗抑郁药使用者中发现患心肌梗死的风险最为显著，OR = 5.4（CI：1.8 - 16.1）。
使用精神药物，尤其是抗抑郁药，与心肌梗死风险增加有关。需要进一步研究以确定使用精神药物与心肌梗死风险之间的关系是否为因果关系。
