酮洛芬在驴（马属驴）体内的药代动力学
Pharmacokinetics of ketoprofen in the donkey (Equus asinus).
作者信息
Oukessou M, Bouljihad M, Van Gool F, Alvinerie M
机构信息
Institut Agronomique et Vétérinaire Hassan II, Rabat, Morocco.
出版信息
Zentralbl Veterinarmed A. 1996 Sep;43(7):423-6. doi: 10.1111/j.1439-0442.1996.tb00470.x.
Abstract
The pharmacokinetic parameters of ketoprofen were determined in four donkeys after a single intravenous injection of a dose of 2.2 mg/kg body weight. The total body clearance (ClB) was 414.0 +/- 98.70 ml/h/kg (mean +/- SD), the volume of distribution at steady state (Vss) 263.10 +/- 55.43 ml/kg and the elimination half-life 1.30 +/- 0.75 h. These values were compared to those obtained in horses.
摘要
在4头驴单次静脉注射2.2毫克/千克体重剂量的酮洛芬后，测定了其药代动力学参数。总体清除率（ClB）为414.0±98.70毫升/小时/千克（平均值±标准差），稳态分布容积（Vss）为263.10±55.43毫升/千克，消除半衰期为1.30±0.75小时。将这些值与在马身上获得的值进行了比较。
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