Doi Y, Masuyama T, Yamamoto K, Mano T, Naito J, Nagano R, Kondo H, Hori M
First Department of Medicine, Osaka University School of Medicine, Suita, Japan.
Angiology. 1996 Nov;47(11):1047-51. doi: 10.1177/000331979604701104.
To clarify the effect of left ventricular (LV) diastolic pressure on the coronary pressure-flow relation in humans, the instantaneous diastolic coronary pressure-Doppler flow velocity relation was analyzed at rest and during papaverine-induced maximal vasodilation in 15 patients with angiographically normal coronary arteries. The values for slope (alpha PF) and zero-flow pressure intercept (Pzf index) of the instantaneous diastolic coronary pressure-flow velocity relation were obtained by a linear regression analysis. Although alpha PF did not correlate with LV end-diastolic pressure (EDP), the Pzf index correlated positively with LVEDP both at rest and during maximal vasodilation (r = 0.64, P < 0.05 and r = 0.58, P < 0.05, respectively). Thus, the back pressure to coronary inflow, as indicated by the Pzf index, may be elevated in patients with increased LVEDP, resulting in the rightward shift of the maximally dilated coronary pressure-flow relation and decreased maximal coronary flow and reserve at any given perfusion pressure.
为阐明左心室舒张期压力对人体冠状动脉压力-血流关系的影响，对15例冠状动脉造影正常的患者在静息状态下以及罂粟碱诱导的最大血管舒张期间的瞬时舒张期冠状动脉压力-多普勒血流速度关系进行了分析。通过线性回归分析得出瞬时舒张期冠状动脉压力-血流速度关系的斜率（αPF）和零血流压力截距（Pzf指数）值。虽然αPF与左心室舒张末期压力（EDP）无相关性，但Pzf指数在静息状态和最大血管舒张期间均与左心室舒张末期压力呈正相关（分别为r = 0.64，P < 0.05和r = 0.58，P < 0.05）。因此，Pzf指数所显示的冠状动脉血流的背压在左心室舒张末期压力升高的患者中可能升高，导致最大扩张冠状动脉压力-血流关系向右移位，并在任何给定灌注压力下最大冠状动脉血流和储备减少。
