流感嗜血杆菌uvrA基因的分离与鉴定
Isolation and characterization of the Haemophilus influenzae uvrA gene.
作者信息
de la Morena M L, Hendrixson D R, St Geme J W
机构信息
Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
出版信息
Gene. 1996 Oct 24;177(1-2):23-8. doi: 10.1016/0378-1119(96)00264-8.
The uvrA gene Haemophilus influenzae (Hi) was cloned and sequenced. Analysis of the deduced amino acid sequence revealed 81% identity and 90% similarity with the Escherichia coli UvrA protein. Consistent with a role of Hi uvrA in DNA repair, a Hi uvrA mutant exhibited increased sensitivity of UV irradiation. Furthermore, Hi uvrA was able to complement a mutation in the E. coli uvrA locus.
流感嗜血杆菌（Hi）的uvrA基因被克隆并测序。对推导的氨基酸序列分析显示，其与大肠杆菌UvrA蛋白有81%的同一性和90%的相似性。与Hi uvrA在DNA修复中的作用一致，Hi uvrA突变体对紫外线照射的敏感性增加。此外，Hi uvrA能够弥补大肠杆菌uvrA基因座中的突变。
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