Feuerman E J, Weissman V
J Int Med Res. 1977;5(3):164-8. doi: 10.1177/030006057700500304.
Fifty patients with refractory psoriasis were treated with a combined method consisting in the application of occlusive dressings with Locacorten Tar ointment at night and of 'open' treatment (without occlusive dressings) with Locasalen ointment during the day. The aim of this trial was to obtain the benefit of the occlusive-dressing method without having to hospitalize the patients. The mean time required for the eradication of psoriatic scales was 3.46 days, while that needed for complete recovery was 14 days. The results clearly indicated that this combined approach has all the advantages of occlusives dressings but allows the patient greater freedom during the day. The very good effect of the treatment is also attributable to the triple action obtained with this combination: the anti-epidermoplastic effect of flumethasone pivalate, the squamolytic effect of salicylic acid, and the keratoplastic action of the tar compound.
五十名顽固性银屑病患者采用联合治疗方法，即夜间使用含卢考可的松焦油软膏的封闭敷料，白天使用卢卡沙林软膏进行“开放”治疗（不使用封闭敷料）。该试验的目的是在无需让患者住院的情况下获得封闭敷料法的益处。消除银屑病鳞屑所需的平均时间为3.46天，而完全康复所需时间为14天。结果清楚表明，这种联合方法具有封闭敷料的所有优点，但能让患者在白天有更大的自由度。治疗效果非常好还归因于这种组合所产生的三重作用：戊酸氟米松的抗表皮增生作用、水杨酸的角质层分离作用以及焦油化合物的角质形成作用。
