Komiyama K, Takeshima H, Umezawa I
Gan. 1977 Apr;68(2):213-9.
Sporamycin is an antitumor antibiotic isolated from the culture filtrate of Streptosporangium strain No. PO-357. Hydrolysate of the antibiotic showed at least 12 kinds of amino acid, and the molecular weight was calculated approximately as 8,500 approximately 9,000. Antitumor activities of Sporamycin were examined on murine tumors according to different schedules of treatment. After nine daily doses of the antibiotic had been given to dd mice bearing Ehrlich ascites carcinoma, significant increase of lifespan was observed at doses of 5.0 approximately 1.3 mg/kg. A marked decrease in tumor size of sarcoma-180 transplanted subcutaneously was observed when the mice were treated by daily or single injection of Sporamycin. Against leukemia P-388 and L-1210 inoculated intraperitoneally into CDF1 mice, the antibiotic increased lifespan of leukemic mice. The antibiotic also inhibited significantly the growth of human tumor cells in vitro.
孢子霉素是从链孢囊菌属PO - 357菌株的培养滤液中分离出的一种抗肿瘤抗生素。该抗生素的水解产物显示至少有12种氨基酸，分子量经计算约为8500至9000。根据不同的治疗方案，对孢子霉素的抗肿瘤活性在小鼠肿瘤上进行了检测。给患有艾氏腹水癌的dd小鼠每日注射九次该抗生素后，在剂量为5.0至1.3毫克/千克时观察到寿命显著延长。当通过每日或单次注射孢子霉素治疗小鼠时，皮下移植的肉瘤 - 180肿瘤大小明显减小。对于腹腔接种到CDF1小鼠体内的白血病P - 388和L - 1210，该抗生素延长了白血病小鼠的寿命。该抗生素在体外也显著抑制人肿瘤细胞的生长。
