Comparative study of Corynebacterium parvum and Corynebacterium liquefaciens on antitumor activity against sarcoma-180.

Corynebacterium parvum and Corynebacterium liquefaciens were comparatively examined for their antitumor activity against sarcoma-180 in ddY mice. In the case of ascitic form, significant antitumor effect was observed when C. parvum was administered on days -4 and -2 or day -2. As for solid form, maximal effect was obtained when C. parvum was administered on day 0. On the other hand, C. liquefaciens exhibited maximal antitumor activity against sarcoma-180, both in ascitic and solid forms, when it was administered on days -4 and -2. However, no significant difference in respect to antitumor activity against sarcoma-180 was seen between C. parvum and C. liquefaciens (ascitic form, F1 118 = 0.09, P greater than 0.05; solid form, F1 53 = 0.03, P greater than 0.05).