Miller H R
Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Roslin, Midlothian, U.K.
Int J Parasitol. 1996 Aug-Sep;26(8-9):801-11. doi: 10.1016/s0020-7519(96)80044-0.
Current understanding of the mucosal immune response to nematode parasites is briefly reviewed with emphasis on the role of the cytokines interleukins-4 and -12 and gamma interferon (IFN gamma) in the development of T-helper responses in rodents. Data from laboratory animals and ruminants indicate that the events associated with a T-helper 2 (Th2) cell response, notably IgE synthesis, eosinophilia and mucosal mastocytosis are protective. Evidence that effector mechanisms may vary for different parasite species is considered. Current gaps in understanding such as the location in the gut and mechanism of antigen processing and presentation as well as the relative contribution of non-immunological effector responses, such as gut motility and mucus secretion, to worm expulsion are discussed.
本文简要回顾了目前对黏膜针对线虫寄生虫免疫反应的理解，重点阐述了细胞因子白细胞介素-4、白细胞介素-12和γ干扰素（IFNγ）在啮齿动物T辅助细胞反应发展中的作用。来自实验动物和反刍动物的数据表明，与T辅助2（Th2）细胞反应相关的事件，特别是IgE合成、嗜酸性粒细胞增多和黏膜肥大细胞增多具有保护作用。文中还考虑了不同寄生虫物种效应机制可能不同的证据。讨论了目前在理解方面的空白，如肠道中抗原加工和呈递的位置及机制，以及非免疫效应反应（如肠道蠕动和黏液分泌）对蠕虫排出的相对贡献。
