Lightowlers M W
Molecular Parasitology Laboratory, University of Melbourne, Werribee, Victoria, Australia.
Int J Parasitol. 1996 Aug-Sep;26(8-9):819-24. doi: 10.1016/s0020-7519(96)80048-8.
Cestode parasites are important because they cause production losses, particularly in the sheep, beef and pig meat industries, and because some species are zoonotic parasites which cause serious disease in humans. Research on the development of vaccines to prevent infection with cestode parasites has concentrated on the taeniid cestodes. Two strategies can be adopted for vaccine research: vaccines against infection in the definitive hosts and vaccines for use in the intermediate hosts. The number and accessibility of definitive hosts would favour these as potential targets for vaccines over intermediate hosts, however little success has been achieved in demonstrating immune-mediated resistance to infection in definitive hosts. In comparison, immunity in the intermediate hosts is a prominent feature of the host-parasite relationship in taeniid cestodes. This has favoured the development of vaccines against Taenia and Echinococcus species in their intermediate hosts. This paper reviews the progress which has been made in vaccination against cestode parasites and the prospects for practical application of these vaccines.
绦虫寄生虫很重要，因为它们会造成生产损失，尤其是在绵羊、牛肉和猪肉行业，还因为一些种类是人畜共患寄生虫，会在人类中引发严重疾病。针对预防绦虫寄生虫感染的疫苗研发研究主要集中在带绦虫纲绦虫上。疫苗研究可采用两种策略：针对终末宿主感染的疫苗和用于中间宿主的疫苗。与中间宿主相比，终末宿主的数量和易接近性使它们更适合作为疫苗的潜在靶点，然而，在证明终末宿主对感染产生免疫介导抗性方面几乎没有取得成功。相比之下，中间宿主的免疫是带绦虫纲绦虫宿主-寄生虫关系的一个显著特征。这有利于在中间宿主中开发针对绦虫属和棘球绦虫属物种的疫苗。本文综述了绦虫寄生虫疫苗接种方面取得的进展以及这些疫苗实际应用的前景。
