Rosenfalck A M, Almdal T, Gotfredsen A, Hilsted J
Department of Internal Medicine and Endocrinology, Hvidovre University Hospital, Copenhagen, Denmark.
Int J Obes Relat Metab Disord. 1996 Nov;20(11):1006-13.
To describe sex- and age-dependent values of total and regional body composition as determined by dual-energy X-ray absorptiometry (DXA) in normal subjects, and furthermore to relate body composition measurements to blood lipids, glucose and insulin concentrations.
A cross-sectional study.
173 (84 male and 89 female) healthy subjects, BMI < 30 kg/m2.
Body composition parameters including data on total bone mineral content (TBMC), total bone mineral density (TBMD), lean body soft tissue mass (LTM), total and regional fat mass (FM) were estimated in all subjects. In 87 of the subjects fasting blood glucose, S-insulin and lipid profile were measured.
The study population was for each sex divided into five decades for which results on body composition and blood lipids are presented. Body weight increased 2 kg per age decade, representing a significant increase in both total FM and relative FM (FM%BW) with age, and in males a central accumulation of FM. LTM decreased significantly in males but not in females, whereas TBMC and TBMD remained constant in males, but decreased in females. A significant correlation between relative FM and S-cholesterol, S-triglyceride, and in males S-insulin was found.
The present study gives coherent data on bone mineral content, lean body soft tissue mass total and regional fat mass for 173 healthy subjects with a BMI below 30 kg/m2. Total body fat mass increases, and lean mass decreases with age. In males a simultaneous central accumulation of fat mass is observed. The well-known relationship between central obesity and lipids is confirmed even in non-obese subjects.
描述通过双能X线吸收法（DXA）测定的正常受试者全身及局部身体成分的性别和年龄依赖性值，并进一步将身体成分测量值与血脂、血糖和胰岛素浓度相关联。
横断面研究。
173名（84名男性和89名女性）健康受试者，BMI<30kg/m²。
在所有受试者中估计身体成分参数，包括全身骨矿物质含量（TBMC）、全身骨矿物质密度（TBMD）、去脂瘦软组织质量（LTM）、全身及局部脂肪量（FM）的数据。在87名受试者中测量了空腹血糖、空腹胰岛素和血脂谱。
按性别将研究人群分为五个年龄段，并给出了各年龄段身体成分和血脂的结果。体重每增加一个年龄十年增加2kg，这表明随着年龄增长，全身FM和相对FM（FM%BW）均显著增加，且男性FM呈中心性堆积。男性LTM显著下降，女性则无明显变化，而男性的TBMC和TBMD保持不变，女性则下降。发现相对FM与总胆固醇、甘油三酯以及男性的空腹胰岛素之间存在显著相关性。
本研究给出了173名BMI低于30kg/m²的健康受试者的骨矿物质含量、去脂瘦软组织质量、全身及局部脂肪量的连贯数据。全身脂肪量随年龄增加，瘦体重随年龄下降。在男性中观察到脂肪量同时出现中心性堆积。即使在非肥胖受试者中，中心性肥胖与血脂之间的众所周知的关系也得到了证实。
