Kwack Won Gun, Kang Yun-Seong, Jeong Yun Jeong, Oh Jin Young, Cha Yoon Ki, Kim Jeung Sook, Yoon Young Soon
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, South Korea.
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Kyung Hee University Hospital, Seoul, South Korea.
J Thorac Dis. 2019 Dec;11(12):5300-5309. doi: 10.21037/jtd.2019.11.54.
Local fat distribution patterns and their local or systemic effects have recently attracted significant attention. The aim of this study was to assess the impact of thoracic adiposity on lung function in a population without respiratory diseases according to sex.
A total of 455 subjects (282 males and 173 females), who had undergone spirometry, and chest and abdominal computed tomography between June 2012 and June 2016 at medical healthcare center, were included. Pericardial fat, intrathoracic fat, subcutaneous thoracic fat, and both visceral and subcutaneous abdominal fat were measured by directly assessing tissue volume using computed tomography. Multiple linear regression analyses adjusted for pack-years of smoking, high-density lipoprotein, and high-sensitivity C-reactive protein were performed to evaluate the association between fat volumes and lung function.
In males, intrathoracic fat and visceral abdominal fat were inversely associated with forced expiratory volume in 1 s (FEV) % predicted (P=0.025, P=0.010, respectively), and subcutaneous thoracic fat volumes showed a negative correlation with both FEV% and forced vital capacity (FVC) % predicted (P=0.019, P=0.045, respectively). In females, subcutaneous thoracic fat demonstrated a negative correlation with both FEV% and FVC % predicted (P=0.031 and P=0.008, respectively).
The influence of local thoracic fat distribution on lung function differed according to sex. Visceral fat and subcutaneous thoracic fat in males and subcutaneous fat in females were significantly associated with decreased lung function.
局部脂肪分布模式及其局部或全身影响最近引起了广泛关注。本研究的目的是根据性别评估无呼吸系统疾病人群中胸壁肥胖对肺功能的影响。
纳入2012年6月至2016年6月期间在医疗保健中心接受肺活量测定以及胸部和腹部计算机断层扫描的455名受试者（282名男性和173名女性）。通过计算机断层扫描直接评估组织体积来测量心包脂肪、胸腔内脂肪、胸壁皮下脂肪以及腹部内脏和皮下脂肪。进行了多项线性回归分析，对吸烟包年数、高密度脂蛋白和高敏C反应蛋白进行了校正，以评估脂肪体积与肺功能之间的关联。
在男性中，胸腔内脂肪和腹部内脏脂肪与1秒用力呼气量（FEV）预测值百分比呈负相关（分别为P = 0.025，P = 0.010），胸壁皮下脂肪体积与FEV%预测值和用力肺活量（FVC）预测值百分比均呈负相关（分别为P = 0.019，P = 0.045）。在女性中，胸壁皮下脂肪与FEV%预测值和FVC预测值百分比均呈负相关（分别为P = 0.031和P = 0.008）。
局部胸壁脂肪分布对肺功能的影响因性别而异。男性的内脏脂肪和胸壁皮下脂肪以及女性的皮下脂肪与肺功能下降显著相关。
