Babarczy E, Vízi Z, Szabó G, Telegdy G
Department of Pathophysiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Neuropeptides. 1996 Oct;30(5):438-42. doi: 10.1016/s0143-4179(96)90007-4.
Brain natriuretic peptide (BNP) is a member of the natriuretic peptide family. The effects of intracerebroventricularly administered BNP (in 0.002-200 ng doses) on the analgesic, tolerance-inducing and dependence-inducing actions of morphine were investigated in adult male CFLP mice. Graded doses of BNP centrally did not affect pain sensitivity itself in a tail-flick test. However, different doses of BNP depressed the acute nociceptive effect of a single subcutaneous dose of morphine (5 mg/kg), and BNP attenuated the development of acute and chronic tolerance to morphine. Withdrawal signs were studied by injecting naloxone (1 mg/kg s.c.). There was no significant difference in symptoms between the tolerant group and animals treated with BNP. The data obtained indicate that BNP can modify the analgesic action of morphine.
脑钠肽（BNP）是利钠肽家族的一员。在成年雄性CFLP小鼠中，研究了脑室内注射不同剂量（0.002 - 200 ng）的BNP对吗啡镇痛、耐受性诱导和依赖性诱导作用的影响。在甩尾试验中，不同剂量的BNP中枢给药本身并不影响疼痛敏感性。然而，不同剂量的BNP可抑制单次皮下注射吗啡（5 mg/kg）的急性伤害性作用，并且BNP可减弱对吗啡急性和慢性耐受性的形成。通过皮下注射纳洛酮（1 mg/kg）研究戒断症状。耐受性组和接受BNP治疗的动物在症状上没有显著差异。所获得的数据表明，BNP可改变吗啡的镇痛作用。
