Wik L, Bircher N G, Safar P
Institute for Experimental Medical Research, University of Oslo, Ullevaal University Hospital, Norway.
Resuscitation. 1996 Oct;32(3):241-50. doi: 10.1016/0300-9572(96)00957-4.
The effects of manual and a new mechanical chest compression device (Heartsaver 2000) during prolonged CPR with respect to haemodynamics and outcome were tested in a prospective, randomized, controlled experimental trial during ventricular fibrillation in 12 dogs of 9-13 kg body weight after 1 min of cardiac arrest. During the first 10 min of CPR the dogs were resuscitated according to the Basic Life Support (BLS) algorithm, followed by 20 min of Advanced Life Support (ALS) algorithm. After 30 min of CPR both manual and mechanical CPR groups were resuscitated following a standardized ALS protocol. During CPR, coronary perfusion pressure and end tidal CO2 were greater with mechanical CPR. All animals were successfully resuscitated and neurological deficit scores were not different. The CPR trauma score was less in the mechanical group. Mechanical external chest compression provided better haemodynamics than the manual technique, though outcome did not differ. Both optimally performed manual and mechanical techniques produce flow sufficient to maintain organ viability for 30 min of CPR after a 1 min arrest interval.
在一项前瞻性、随机、对照实验中，对12只体重9 - 13千克的犬在心脏骤停1分钟后发生心室颤动期间，使用手动和一种新型机械胸外按压装置（Heartsaver 2000）进行长时间心肺复苏时的血流动力学和结果影响进行了测试。在心肺复苏的前10分钟，按照基础生命支持（BLS）算法对犬进行复苏，随后按照高级生命支持（ALS）算法进行20分钟复苏。在心肺复苏30分钟后，手动和机械心肺复苏组均按照标准化的ALS方案进行复苏。在心肺复苏期间，机械心肺复苏时冠状动脉灌注压和呼气末二氧化碳更高。所有动物均成功复苏，神经功能缺损评分无差异。机械组的心肺复苏创伤评分更低。机械胸外按压比手动技术提供了更好的血流动力学，尽管结果没有差异。在1分钟的骤停间隔后，最佳实施的手动和机械技术都能产生足以维持器官活力30分钟心肺复苏的血流量。
