Unal A, Güven K, Gürsoy S, Kontas O, Baran L
Department of Internal Medicine, Erciyes University Medical School, Kayseri, Turkey.
Int J Hematol. 1996 Oct;64(3-4):297-300.
Recently, a stimulation test with colony stimulation factors was found useful to predict bone marrow cellularity. We examined the usefulness of this test to predict the bone marrow involvement in patients with malignant lymphoma. A single dose of GM-CSF (5 micrograms/kg) was given subcutaneously to 12 patients with malignant lymphoma. Six patients had normocellular bone marrow. Five of these 6 patients showed an increase in neutrophils of more than 5 x 10(9)/l after GM-CSF administration. The remaining 6 patients who had bone marrow lymphoma involvement had a neutrophil count of less than 5 x 10(9)/l. Therefore, the change in neutrophil count with a cut-off value of 5 x 10(9)/l distinguished the marrow lymphoma involvement with a sensitivity and specificity of 83% and 100%, respectively. The nadir neutrophil count was significantly higher in patients with normal marrow than in patients with marrow involvement after chemotherapy (P < 0.02). In conclusion, the GM-CSF stimulation test is useful to predict the marrow involvement in patients with malignant lymphoma.
最近，发现集落刺激因子刺激试验有助于预测骨髓细胞密度。我们研究了该试验在预测恶性淋巴瘤患者骨髓受累情况方面的实用性。对12例恶性淋巴瘤患者皮下注射单剂量的粒细胞巨噬细胞集落刺激因子（GM-CSF，5微克/千克）。6例患者骨髓细胞密度正常。这6例患者中有5例在给予GM-CSF后中性粒细胞增加超过5×10⁹/升。其余6例有骨髓淋巴瘤受累的患者中性粒细胞计数低于5×10⁹/升。因此，以5×10⁹/升为临界值的中性粒细胞计数变化区分骨髓淋巴瘤受累情况，敏感性和特异性分别为83%和100%。化疗后骨髓正常的患者中性粒细胞计数最低点显著高于有骨髓受累的患者（P<0.02）。总之，GM-CSF刺激试验有助于预测恶性淋巴瘤患者的骨髓受累情况。
