昼夜节律光相移不受组胺受体拮抗剂的影响。

Circadian rhythm photic phase shifts are not altered by histamine receptor antagonists.

作者信息

Eaton S J, Eoh S, Meyer J, Hoque S, Harrington M E

机构信息

Department of Psychology, Smith College, Northampton, MA 01063, USA.

出版信息

Brain Res Bull. 1996;41(4):227-9. doi: 10.1016/s0361-9230(96)00179-7.

DOI:10.1016/s0361-9230(96)00179-7

PMID:8924032

Abstract

Histamine may play a role in synchronizing endogenous circadian rhythms with exogenous photic cues. Direct application of histamine to the suprachiasmatic nucleus, the site of the mammalian circadian pacemaker, phase shifts the circadian rhythm in neural activity [7]. Intraventricular injections of histamine also phase shift circadian rhythms [14]. The magnitude and direction of the phase shifting effects of histamine depend on circadian phase in a manner similar to light [7,14]. Depletion of brain histamine levels by inhibition of histamine synthesis reduces phase shifts to light [10].

摘要

组胺可能在内源性昼夜节律与外源性光信号同步过程中发挥作用。将组胺直接应用于视交叉上核（哺乳动物昼夜节律起搏器所在部位），可使神经活动的昼夜节律发生相移[7]。脑室内注射组胺也会使昼夜节律发生相移[14]。组胺相移效应的幅度和方向取决于昼夜节律相位，其方式与光相似[7,14]。通过抑制组胺合成来降低脑内组胺水平，会减少对光的相移[10]。