Abraham H D, Aldridge A M, Gogia P
Department of Psychiatry, Tufts New England Medical Center, Boston, MA, USA.
Neuropsychopharmacology. 1996 Apr;14(4):285-98. doi: 10.1016/0893-133X(95)00136-2.
Hallucinogenic drugs have been inhaled, ingested, worshipped, and reviled since prehistory. With the purification and synthesis of bontanical preparations and the ensuing discovery of chemically unique agents, hope was raised regarding their therapeutic potential, but this hope has been clouded by an epidemic of abuse and an inventory of adverse effects. This review examines aspects of that controversy, including the history of hallucinogens, epidemiology of current hallucinogen abuse, the association of LSD use with prolonged psychoses and hallucinogen persisting perception disorder, and the efforts to demonstrate the drug's therapeutic efficacy. Human subject ramifications in hallucinogen experimentation are discussed. Future lines of research are suggested in human, animal, and tissue culture paradigms.
自史前时代以来，致幻药物就一直被吸入、摄入、崇拜和诋毁。随着植物制剂的提纯和合成以及随后化学性质独特的药物的发现，人们对其治疗潜力的期望有所提高，但这种期望因滥用流行和一系列不良反应而蒙上阴影。本综述探讨了这一争议的各个方面，包括致幻剂的历史、当前致幻剂滥用的流行病学、使用麦角酸二乙酰胺（LSD）与长期精神病和致幻剂持续性感知障碍的关联，以及证明该药物治疗效果的努力。讨论了致幻剂实验中人体受试者的影响。还提出了在人体、动物和组织培养模式下未来的研究方向。
