Alvarez Sintes R, Alvarez Sintes R, Alvarez Castro M R
Medicina Interna y Cuidados Intensivos, Hospital Clínico-Quirúrgico Docente, Calixto García, La Habana, Cuba.
An Med Interna. 1995 Sep;12(9):438-41.
Bronchodilator effect and toxicity of theophylline 300 mg twice a day (E1), Salbutamol 4 mg tid (E2), their combination in higher (200/4 mg, E3), and lower doses (100/2 mg E4), and placebo calcium lactate (300 mg) tid (E5) were compared in 30 patients with bronchial asthma in a randomized cross over trial. Statistically significant second (FEV1) was observed in all the active treatment groups (E1, to E4) compared with placebo (E5). Almost all the regimens were tolerated well and no patient showed major adverse reaction or cardiotoxicity necessitating withdrawal of the drug. On the other hand, minor adverse reactions were common and the high dose combination (E3) was found to have more adverse reactions than the low dose combination and either drug used alone.
在一项随机交叉试验中，对30例支气管哮喘患者比较了每日两次300毫克茶碱（E1）、每日三次4毫克沙丁胺醇（E2）、高剂量组合（200/4毫克，E3）和低剂量组合（100/2毫克，E4）以及安慰剂乳酸钙（300毫克）每日三次（E5）的支气管扩张作用和毒性。与安慰剂组（E5）相比，在所有活性治疗组（E1至E4）中观察到第二秒用力呼气容积（FEV1）有统计学意义的改善。几乎所有治疗方案耐受性良好，没有患者出现需要停药的严重不良反应或心脏毒性。另一方面，轻微不良反应很常见，发现高剂量组合（E3）比低剂量组合以及单独使用任何一种药物有更多的不良反应。
