通过高效液相色谱法研究一种新型生长激素释放激素（GHRH）类似物的化学稳定性。

Investigation of the chemical stability of a new growth hormone-releasing hormone (GHRH) analogue by HPLC.

作者信息

Idei M, Mezö I, Szabó E Z, Kéri G

机构信息

I. Institute of Biochemistry, Semmelweis University, Medical School, Budapest, Hungary.

出版信息

Biomed Chromatogr. 1996 Mar-Apr;10(2):89-91. doi: 10.1002/(SICI)1099-0801(199603)10:2<89::AID-BMC560>3.0.CO;2-Q.

DOI:10.1002/(SICI)1099-0801(199603)10:2<89::AID-BMC560>3.0.CO;2-Q

PMID:8924733

Abstract

The stability of a new active growth hormone-releasing hormone analogue (D-Ala2,Nle27,(gamma-amino-butyric acid)30-GHRH(1-30)-NH2) was investigated during storage at different temperatures in aqueous solution. Samples stored for various periods of time were analysed by HPLC. It is concluded that in aqueous solution D-Ala2, Nle27,(gamma-amino-butyric acid)30-growth hormone-releasing hormone (1-30)-NH2 is stable: at least for 36 days at 4 degrees C; for 28 days at 25 degrees C; and for 10 days at 37 degrees C.

摘要

研究了一种新型活性生长激素释放激素类似物（D-丙氨酸2，Nle27，（γ-氨基丁酸）30-GHRH（1-30）-NH2）在不同温度的水溶液中储存期间的稳定性。通过高效液相色谱法分析储存不同时间段的样品。得出的结论是，在水溶液中，D-丙氨酸2，Nle27，（γ-氨基丁酸）30-生长激素释放激素（1-30）-NH2是稳定的：在4℃至少稳定36天；在25℃稳定28天；在37℃稳定10天。