[卵胞浆内单精子注射与克兰费尔特综合征]
[Intracytoplasmic sperm injection and Klinefelter syndrome].
作者信息
Sèle B, Cozzi J, Chevret E, Monteil M, Rousseaux S, Pelletier R
机构信息
Equipe de Biologie de la Reproduction, INSERM U 309, Institut Albert Bonniot, Faculté de Médecine de Grenoble, La Tronche.
出版信息
Contracept Fertil Sex. 1996 Jul-Aug;24(7-8):581-4.
PMID:8924960
Abstract
Sperm cytogenetic study in two patients with Klinefelter's syndrome have demonstrated that there existed a risk low but highly significant, to transmit a sex chromosome abnormality to the offsprings. This result argues for a systematic karyotype before ICSI, and if such mosaïcs can be treated by ICSI, they must be firstly associated to a genetic counselling.
摘要
对两名克兰费尔特综合征患者的精子细胞遗传学研究表明，将性染色体异常遗传给后代存在低但高度显著的风险。这一结果支持在卵胞浆内单精子注射（ICSI）前进行系统的核型分析，并且如果此类嵌合体可通过ICSI治疗，必须首先进行遗传咨询。
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