[Changes in the cerebrovascular adrenergic innervation and the neurons of the locus coeruleus in the brain stem during action on the hypothalamus].

By means of histochemical and neurohistochemical study of adrenergic nerve structures of cerebral and pia mater vessels and certain cerebral trunk nuclei relating to intracerebral monoaminergic system cerebrovascular desymphathization was found to develop in six control and fifteen experimental rabbits under conditions of dosaged stereotaxic irritation of posterior hypothalamic field. The phenomenon described is temporal and can be partly compensated by activation of macula caerulea noradrenaline-containing neurons. Unchanged and experimentally changed neurons were described in macula caerulea nuclea on the base of simultaneously performed analysis of the cerebral trunk serial-stepped sections stained by Nissl method. Changes in neurons were accompanied with the satellite neuroglia progressive reaction and capillary hyperemia. Reorganisations of cytoplasm, nucleus and nucleolus observed in neurons were incomplete and basically morphofunctional, reflecting the compensatory processes.