Capillary gas chromatographic method for the determination of n-butyl-p-aminobenzoate and lidocaine in plasma samples.
作者信息
Grouls R J, Machielsen E, Korsten H H, Hellebrekers L J, Breimer D D, Ackerman E W
机构信息
Department of Pharmaceutical Services, Catharina Hospital, Eindhoven, Netherlands.
出版信息
J Chromatogr B Biomed Appl. 1995 Nov 3;673(1):51-7. doi: 10.1016/0378-4347(95)00237-d.
PMID:8925074
Abstract
A fast capillary gas chromatographic method with nitrogen-selective detection is described that allows selective and reproducible quantification of n-butyl-p-aminobenzoate (BAB) and lidocaine in plasma. The sampling and sample storage conditions are critical for the quantification of BAB. Diisopropyl fluorophosphate, an organo-phosphorus pesticide, has to be added during sampling to prevent the rapid decomposition of BAB by cholinesterases.
摘要
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