Backman K S, Shaughnessy M A, Harris K E, Grammer L C
Division of Allergy-Immunology, Northwestern Memorial Hospital, Chicago, Illinois, USA.
J Occup Environ Med. 1996 Apr;38(4):347-51. doi: 10.1097/00043764-199604000-00011.
The objective of this study was to determine whether total serum IgE levels are elevated in workers with trimellitic anhydride-induced asthma as compared with anhydride-exposed workers without an occupational immunologic syndrome. Sera from 12 highly exposed workers with trimellitic anhydride-induced asthma, and from 31 similarly exposed workers without occupational immunologic disease, were assayed for total immunoglobulin E (IgE) levels by Total IgE II FAST analysis. The mean total IgE levels were 176.74 ng/mL and 34.55 ng/mL respectively. The difference between the two groups was statistically significant, but considerable overlap of IgE levels between groups was seen. In conclusion, although mean total IgE levels are significantly different between TMA-exposed workers with or without occupational asthma, the significant amount of overlap and poor sensitivity of the test preclude the use of this assay in the individual evaluation of these workers.
本研究的目的是确定与暴露于酸酐但无职业免疫综合征的工人相比，偏苯三酸酐诱发哮喘的工人血清总IgE水平是否升高。通过总IgE II快速分析法检测了12名患有偏苯三酸酐诱发哮喘的高暴露工人以及31名同样暴露但无职业免疫疾病的工人的血清总免疫球蛋白E（IgE）水平。两组的平均总IgE水平分别为176.74 ng/mL和34.55 ng/mL。两组之间的差异具有统计学意义，但两组之间的IgE水平有相当大的重叠。总之，虽然暴露于偏苯三酸酐且患有或未患有职业性哮喘的工人之间的平均总IgE水平有显著差异，但该检测方法存在大量重叠且敏感性较差，因此无法用于对这些工人进行个体评估。
