Dusi S, Donini M, Wientjes F, Rossi F
Institute of General Pathology, University of Verona, Italy.
FEBS Lett. 1996 Apr 1;383(3):181-4. doi: 10.1016/0014-5793(96)00248-7.
In this paper, we show that the p125 ras guanosine triphosphatase-activating protein (p125 GAP) is present in the cytosol of human neutrophils and is transiently tyrosine phosphorylated and translocated to the membranes upon cell activation with formyl-methionyl-leucyl-phenylalanine (FMLP). When concanavalin A (ConA) or phorbol 12-myristate 13-acetate (PMA), which both induced a long-lasting respiratory burst, were used as stimuli, tyrosine phosphorylation and translocation of p125 GAP did not occur.
