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剖宫产术后子宫内膜炎的短期抗生素治疗

[Short-term antibiotic therapy of post-cesarean-section endometritis].

作者信息

Rodríguez-Ballesteros R, Alarcón-Aburto V M, Madrigal-de la Campa M A, de la Campa M, Valerio-Castro E

机构信息

Departmento de Gineco-Obstetricia, Hospital Central Militar, México, D.F.

出版信息

Ginecol Obstet Mex. 1996 Aug;64:359-62.

PMID:8925987
Abstract

Post-cesarean-section endometritis therapy usually combines an intravenous administered antibiotic followed, once fever has remitted, by an oral or intramuscular course of 7-10 days of the same antibiotic. From November 1993 to May 1994 and trying to reduce the length of the treatment we conducted a randomized, comparative study between the conventional post-C-section endometritis treatment used at the Hospital Central Militar (long course) and a short parenteral treatment with the same antibiotics. Thirty one patients were randomized in the short course group and 32 in the long course group. Only in the long course group there was a patient with persistence of infection after ten days of antibiotic treatment (p > 0.05). The short course regimen brought additional advantages as reduction in treatment days as well as discomfort for the intramuscular administration of antibiotics. This observation suggests that a short course of antibiotics based on the patient's clinical response is a safe and less expensive alternative in the treatment of post-C-section endometritis.

摘要

剖宫产术后子宫内膜炎的治疗通常是先静脉注射抗生素,一旦发热消退,再口服或肌肉注射同一种抗生素7至10天。1993年11月至1994年5月期间,为了缩短治疗时间,我们在中央军事医院对传统的剖宫产术后子宫内膜炎治疗方法(长疗程)与使用相同抗生素的短期非肠道治疗方法进行了一项随机对照研究。31例患者被随机分配至短疗程组,32例患者被分配至长疗程组。仅在长疗程组中有1例患者在抗生素治疗10天后仍有感染持续存在(p>0.05)。短疗程方案具有额外的优势,如治疗天数减少以及避免了肌肉注射抗生素带来的不适。这一观察结果表明,根据患者的临床反应采用短疗程抗生素治疗是治疗剖宫产术后子宫内膜炎的一种安全且成本较低的选择。

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