Takeda S, Wu E Y, Ramanathan M, Estrera A S, Hsia C C
Department of Medicine and Surgery, University of Texas Southwestern Medical Center, Dallas 75235-9034, USA.
J Appl Physiol (1985). 1996 Apr;80(4):1304-12. doi: 10.1152/jappl.1996.80.4.1304.
To determine the temporal progression and magnitude of functional compensation in immature dogs raised to maturity after extensive lung resection, we performed right pneumonectomy (R-Pnx) or right thoracotomy without pneumonectomy (Sham) in matched foxhounds at 2 mo of age. At 4, 8, 20, 40, and 60 wk after surgery, static transpulmonary pressure-lung volume relationships were determined. Lung diffusing capacity, membrane diffusing capacity, pulmonary capillary blood volume, pulmonary blood flow, septal lung tissue volume, and lung volumes were measured simultaneously by a rebreathing technique. During maturation, total lung capacity, lung volume at a given distending pressure, and compliance were lower in the R-Pnx group than in the Sham group (P < 0.05). Pulmonary viscous resistance at maturity was elevated after R-Pnx. There were no significant differences in total lung diffusing capacity, membrane diffusing capacity, pulmonary capillary blood volume, pulmonary blood flow, and septal lung tissue volume between groups. Compensation of alveolar-capillary gas exchange was complete by 4-8 wk after R-Pnx, but compensation of mechanical properties remained incomplete throughout maturation. Relative magnitude of compensation after R-Pnx was greater in immature dogs than in adult dogs studied previously by similar techniques.
为了确定在广泛肺切除术后饲养至成熟的未成熟犬中功能代偿的时间进程和程度，我们在2月龄的匹配猎狐犬中进行了右肺切除术（R - Pnx）或不进行肺切除术的右胸切开术（假手术）。在术后4、8、20、40和60周，测定静态跨肺压-肺容积关系。通过重复呼吸技术同时测量肺扩散容量、膜扩散容量、肺毛细血管血容量、肺血流量、肺间隔组织容积和肺容积。在成熟过程中，R - Pnx组的总肺容量、给定扩张压力下的肺容积和顺应性低于假手术组（P < 0.05）。R - Pnx术后成熟时肺粘性阻力升高。两组之间的总肺扩散容量、膜扩散容量、肺毛细血管血容量、肺血流量和肺间隔组织容积没有显著差异。R - Pnx术后4 - 8周肺泡-毛细血管气体交换的代偿完成，但机械性能的代偿在整个成熟过程中仍不完全。通过类似技术研究发现，R - Pnx术后未成熟犬的代偿相对程度大于成年犬。
