Singer P, Mozayani A
Medical Examiner's Office, Edmonton, AB, Canada.
J Anal Toxicol. 1995 Oct;19(6):529-30. doi: 10.1093/jat/19.6.529.
The results of an accidental overdose fatality in a child involving disopyramide and sulindac are reported in this paper. Quantitation of disopyramide was performed by gas chromatography using codeine as the internal standard. Sulindac was assayed by high- performance liquid chromatography using ketoprofen as the internal standard. The postmortem blood concentrations of disopyramide and sulindac were 41.3 and 12.2 mg/L, respectively. The concentrations of disopyramide and sulindac were also quantitated in the liver, in bile, and in urine.
本文报告了一例儿童意外过量服用丙吡胺和舒林酸致死的案例。以可待因作为内标，采用气相色谱法对丙吡胺进行定量分析。以酮洛芬作为内标，采用高效液相色谱法对舒林酸进行测定。丙吡胺和舒林酸的尸检血药浓度分别为41.3mg/L和12.2mg/L。还对肝脏、胆汁和尿液中的丙吡胺和舒林酸浓度进行了定量分析。
