Schade D S, Eaton R P
Horm Metab Res. 1977 Jul;9(4):253-7. doi: 10.1055/s-0028-1093546.
To explore the effect of physiological elevations of glucagon on plasma triglyceride concentration, glucagon was infused for thirty minutes at 3.0 ng/kg/min into both normal and insulin dependent diabetic subjects. The effects of this hormonal infusion on plasma triglyceride, free fatty acids, glucose, and insulin were compared to a control saline infusion study. A differential effect of glucagon on plasma triglyceride concentration between normal and diabetic subjects was observed. In normal subjects, glucagon infusion was accompanied by a concomitant increase in endogenous insulin secretion and free fatty acid levels, and no observable effect on circulating plasma triglyceride concentration. In contrast, in diabetic subjects, no change in insulin or free fatty acid concentration occurred during glucagon infusion and circulating plasma triglyceride concentration declined after twenty minutes of hormone infusion. These results suggest that plasma triglyceride concentration may be modulated, at least in part, by alterations in circulating plasma glucagon in concert with insulin secretion and free fatty acid availability in man.
为探究胰高血糖素的生理性升高对血浆甘油三酯浓度的影响，分别以3.0纳克/千克/分钟的速度向正常受试者和胰岛素依赖型糖尿病受试者输注胰高血糖素30分钟。将这种激素输注对血浆甘油三酯、游离脂肪酸、葡萄糖和胰岛素的影响与生理盐水对照输注研究进行比较。观察到胰高血糖素对正常受试者和糖尿病受试者血浆甘油三酯浓度的影响存在差异。在正常受试者中，输注胰高血糖素的同时内源性胰岛素分泌和游离脂肪酸水平随之增加，且对循环血浆甘油三酯浓度无明显影响。相比之下，在糖尿病受试者中，输注胰高血糖素期间胰岛素或游离脂肪酸浓度无变化，且在输注激素20分钟后循环血浆甘油三酯浓度下降。这些结果表明，人体血浆甘油三酯浓度可能至少部分地受到循环血浆胰高血糖素变化的调节，同时与胰岛素分泌和游离脂肪酸的可用性有关。
