Paolisso G, Sgambato S, Giunta R, Varricchio M, D'Onofrio F
Istituto di Gerontologia e Geriatria, 1st Medical School, University of Naples, Italy.
Diabete Metab. 1990 Jan-Feb;16(1):42-7.
The present study aimed at investigating the respective effects of continuous and pulsatile intravenous delivery of glucagon in insulin-dependent diabetic subjects. The study was performed in seven insulin-dependent diabetic subjects proven to have no residual insulin secretion. In random order and in different days each subject was submitted to glucagon delivery given continuously (58 ng/min) and in a pulsatile (377 ng/min during 2 min followed by 11 min during which no glucagon was infused) manner. In this conditions plasma glucose levels were significantly higher during pulsatile glucagon delivery. In particular in the last 65 min plasma glucose levels reached 10.8 +/- 0.3 vs 12.9 +/- 0.4 mmol/l (p less than 0.05) during continuous and pulsatile glucagon delivery respectively. Similarly plasma lipid changes also evidenced a greater effects of pulsatile rather than continuous hormone administration in producing the metabolic derangements classically encountered in insulin-dependent diabetic subjects. In conclusion, pulsatile glucagon delivery seem to produce greater metabolic effects than continuous hormone delivery.
本研究旨在调查持续静脉输注胰高血糖素和脉冲式静脉输注胰高血糖素对胰岛素依赖型糖尿病患者的各自影响。该研究在7名经证实无残余胰岛素分泌的胰岛素依赖型糖尿病患者中进行。在不同的日子里，每位受试者以随机顺序分别接受持续（58纳克/分钟）和脉冲式（2分钟内377纳克/分钟，随后11分钟不输注胰高血糖素）的胰高血糖素输注。在这种情况下，脉冲式输注胰高血糖素期间血浆葡萄糖水平显著更高。特别是在最后65分钟，持续和脉冲式输注胰高血糖素期间血浆葡萄糖水平分别达到10.8±0.3和12.9±0.4毫摩尔/升（p<0.05）。同样，血浆脂质变化也表明，在产生胰岛素依赖型糖尿病患者中常见的代谢紊乱方面，脉冲式激素给药比持续激素给药的影响更大。总之，脉冲式输注胰高血糖素似乎比持续输注激素产生更大的代谢效应。
