Balbi C, Di Grazia F, Piscitelli V, Martini S, Cardone A, Balbi G C
II Università degli Studi, Napoli, II Clinica Ginecologica ed Ostetrica.
Minerva Ginecol. 1996 May;48(5):175-9.
Specific types of human papillomavirus (HPV) are currently implicated as etiologic agent of benign and malignant lesions of the genital tract. Previous studies highlighted the presence of early proteins (ICSP 11/12) of Herpes simplex virus type 2 (HSV-2) mainly in HPV infected lesions of the cervix. This paper reports a retrospective study on the clinical course of benign cervical alterations in a 70 women population followed-up for 24 months. HPV and HSV-2 (late and early) antigens were detected by immunoperoxidase; HPV 6/11 and 16/18 were identified by in situ hybridization. All CIN III, vs only one CIN I progressed. The majority of regressions (55%) was CIN I, and 61% was characterized by the negativization of viral markers. There was a cyclic and/or chronic expression of viral antigens in progressed and persistent cases (67% and 53%, respectively). Furthermore, a significant correlation between progression and the presence of ICSP 11/12 protein has been found (89% of cases). The simultaneous detection of ICSP 11/12 and HPV 16/18 in 78% of progressed, and in 13% of persistent lesions was noteworthy. This association (ICSP 11/12 and HPV DNA 16/18) may be considered as a risk factor for progression of the lesions, and supports the hypothesis of a synergism of both viruses in the natural history of cervical cancer: the continuous expression of ICSP 11/12 during herpetic recurrences might act as a mutagenic factor in HPV infected tissues.
目前，特定类型的人乳头瘤病毒（HPV）被认为是生殖道良性和恶性病变的病原体。先前的研究强调，单纯疱疹病毒2型（HSV - 2）的早期蛋白（ICSP 11/12）主要存在于子宫颈HPV感染的病变中。本文报告了一项对70名女性人群进行为期24个月随访的子宫颈良性病变临床病程的回顾性研究。通过免疫过氧化物酶检测HPV和HSV - 2（晚期和早期）抗原；通过原位杂交鉴定HPV 6/11和16/18。所有CIN III病例中，只有1例CIN I进展。大多数病变消退（55%）为CIN I，且61%的特征是病毒标志物转阴。在病变进展和持续的病例中分别有67%和53%存在病毒抗原的周期性和/或慢性表达。此外，还发现病变进展与ICSP 11/12蛋白的存在之间存在显著相关性（89%的病例）。值得注意的是，在78%的病变进展病例和13%的病变持续病例中同时检测到ICSP 11/12和HPV 16/18。这种关联（ICSP 11/12和HPV DNA 16/18）可能被视为病变进展的危险因素，并支持两种病毒在子宫颈癌自然病程中协同作用的假说：疱疹复发期间ICSP 11/12的持续表达可能在HPV感染组织中起诱变作用。
