[复发性或阻塞性支气管炎患儿体内的弹性蛋白衍生肽和抗弹性抗体]

[Elastin-derived peptides and anti-elastic antibodies in children with recurrent or obstructive bronchitis].

作者信息

Polańska B, Jankowski A

机构信息

Katedra Propedeutyki Pediatrii i Klinika Immunologii Wieku Rozwojowego Akademii Medyeznej we Wrocławiu.

出版信息

Pediatr Pol. 1996 Sep;71(9):759-63.

PMID:8927483

Abstract

The aim of the study was to examine the effects of bronchitis on elastin-derived peptides (EP) and antielastin antibodies (AEAb) in serum. Using an ELISA technique, these parameters were assessed in children aged 6 months to 15 years: 36 had recurrent bronchitis (RB), 34 had obstructive bronchitis (OB) and 37 were healthy children (C). A comparison of the levels of the investigated compounds in the acute phase (I) and stage without signs of diseases (II) was studied. The EP data show non-significant changes in the RB and OB groups in comparison with group C. Children with OB had significantly lower levels of AEAb in IgA, IgG and IgM class antibodies, while those with RB in the IgG class in comparison with group C in both examinations. In examination 1, AEAb in IgA and IgM classes were significantly lower in children with OB than with RB.

摘要

本研究的目的是检测支气管炎对血清中弹性蛋白衍生肽（EP）和抗弹性蛋白抗体（AEAb）的影响。采用酶联免疫吸附测定（ELISA）技术，对6个月至15岁的儿童进行了这些参数的评估：36例患有复发性支气管炎（RB），34例患有阻塞性支气管炎（OB），37例为健康儿童（C）。研究了急性期（I）和无疾病体征阶段（II）所研究化合物水平的比较。EP数据显示，与C组相比，RB组和OB组无显著变化。OB患儿IgA、IgG和IgM类抗体中的AEAb水平显著较低，而RB患儿在两次检查中IgG类抗体中的AEAb水平与C组相比也是如此。在检查1中，OB患儿IgA和IgM类中的AEAb显著低于RB患儿。