Flisiak R, Wiercińska-Drapało A, Prokopowicz D
Klinika Obserwacyjno-Zakaźna Akademii Medycznej w Białymstoku.
Przegl Epidemiol. 1996;50(3):253-7.
Cell mediated as well as humoral immune response was evaluated in 14 lyme arthritis patients. Significant decrease of T cells percentage was observed in comparison to normal values. It was related particularly to CD4+ subset and resulted in significant decrease of CD4+/CD8+ ratio. Statistically significant increase of B cells percentage was accompanied by elevated concentrations of immunoglobulin M, complement components C3 and C4. Immunoglobulins A and G, as well as circulating immune complexes remained on the normal level. These results indicate suppression of cellular and activation of humoral immune response in patients with Lyme arthritis.
对14例莱姆关节炎患者的细胞介导免疫反应和体液免疫反应进行了评估。与正常值相比，观察到T细胞百分比显著下降。这尤其与CD4+亚群有关，并导致CD4+/CD8+比值显著下降。B细胞百分比的统计学显著增加伴随着免疫球蛋白M、补体成分C3和C4浓度的升高。免疫球蛋白A和G以及循环免疫复合物保持在正常水平。这些结果表明莱姆关节炎患者存在细胞免疫抑制和体液免疫反应激活。
