Abdulkadyrov K M, Rukavitsyn O A, Bessmel'tsev S S, Martynkevich I A, Saltykova L B, Sidorova Zh Iu, Blinov M N, Shcherbakova E G, Shilova E R
Ter Arkh. 1996;68(7):27-31.
To elucidate feasibility of accurate diagnosis of chronic myeloid leukemia (CML) without cytogenetic and molecular-genetic investigations as well as to specify CML diagnostic criteria, clinicohematological parameters were compared in two groups of patients: with Ph'-chromosome and/or rearrangement of fragment bcr (group 1), with unknown karyotype in whom detection of bcr fragment rearrangement was not made. Clinicohematological parameters in both groups were close in absolute value and underwent parallel changes in the course of leukemia progression. In group 1, patients in progressive and blastic phase compared to patients in chronic phase had a 14-fold increase in the number of additional cytogenetic anomalies. In patients with tumor transformation fragment bcr underwent rearrangement according to type B2A2. Thus, the diagnosis of typical CML variants is feasible without detection of Ph'-chromosome and/or rearrangement of bcr fragment. It is especially true and essential for patients in the chronic phase. The data obtained provide more accurate diagnostic criteria of CML.
为阐明在不进行细胞遗传学和分子遗传学检查的情况下准确诊断慢性髓性白血病（CML）的可行性以及明确CML诊断标准，对两组患者的临床血液学参数进行了比较：一组为有Ph'染色体和/或bcr片段重排的患者（第1组），另一组为未进行bcr片段重排检测且核型未知的患者。两组患者的临床血液学参数绝对值相近，且在白血病进展过程中呈现平行变化。在第1组中，进展期和急变期患者与慢性期患者相比，额外细胞遗传学异常数量增加了14倍。在肿瘤转化患者中，bcr片段根据B2A2型进行重排。因此，在未检测到Ph'染色体和/或bcr片段重排的情况下，诊断典型CML变异型是可行的。这对于慢性期患者尤为正确且至关重要。所获得的数据提供了更准确的CML诊断标准。
