Enevoldsen M T, Rørdam P, Schroeder T V
Karkirurgisk afdeling RK, Rigshospitalet, København.
Ugeskr Laeger. 1996 Sep 2;158(36):5011-4.
The effect of intra-arterial local thrombolysis or peripheral arterial occlusions seems to be well documented. As assessed by angiography, primary recanalisation is achieved in 65-90%. Using recombinant tissue plasminogen activator thrombolysis is achieved more frequently (90% vs 65-85%) and faster (4-8 hours vs 12-48 hours) than when using streptokinase or urokinase. The most frequently used dosages are streptokinase 5000 IU/h, and recombinant tissue plasminogen activator 0.5 mg/h. So far, results from randomized trials between thrombolytic therapy and surgery have not been published.
动脉内局部溶栓治疗对周围动脉闭塞的效果似乎已有充分记录。通过血管造影评估，初次再通率为65% - 90%。与使用链激酶或尿激酶相比，使用重组组织型纤溶酶原激活剂时溶栓更频繁（90%对65% - 85%）且更快（4 - 8小时对12 - 48小时）。最常用的剂量是链激酶5000 IU/小时和重组组织型纤溶酶原激活剂0.5毫克/小时。到目前为止，溶栓治疗与手术之间的随机试验结果尚未发表。
